Similarities of genetic (spontaneous) hypertension. Man and rat.

Similarities of genetic (spontaneous) hypertension. Man and rat.

The rat with spontaneous genetic hypertension is not a suitable model of human essential hypertension.

Brief Reviews: Lipid-Membrane Interactions and the Pathogenesis of Ischemic Damage in the Myocardium. Arnold M. Katz and Frank C. Messineo 1 Role of Changes in Microsomal Calcium Uptake in the Effects of Reperfusion of Ca-Deprived Rat Hearts. Lauri E. Alto and Naranjan S. Dhalla 17 Reduction of Maximal Coronary Vasodilator Capacity in Conscious Dogs with Severe Right Ventricular Hypertrophy. Pa...

Genetic analysis of rat chromosome 1 and the Sa gene in spontaneous hypertension.

Linkage studies in segregating populations derived from the spontaneously hypertensive rat (SHR) indicate that a blood pressure quantitative trait locus exists on rat chromosome 1 in the vicinity of the Sa gene. On the basis of these findings and the observation of increased renal expression of the Sa gene in SHR versus normotensive rats, the Sa gene has been proposed as a candidate gene for sp...

Vasopressin in the rat with spontaneous hypertension.

Because vasopressin is one of the most potent naturally occurring pressor agents, and because of its importance in the regulation of blood volume and composition, we have undertaken a study of the role of vasopressin in the pathogenesis of the hypertension in the Okamoto-Aoki spontaneously hypertension (SH) rat. In SH rats, systolic blood pressure increased from 135 +/- 3 (SE) mmHg at age 33 da...

Similarities of essential and spontaneous hypertension. Volume and number of blood cells.

Spontaneously hypertensive rats have long been used as an animal counterpart of human essential hypertension. The validation of this strain as a model rests mainly on the "clinical" similarity of the two syndromes, but it has scarcely been founded on numerical comparison of measurable parameters. We investigated three hematological indexes previously recognized to be altered in spontaneously hy...